Blog
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Ordinary Epigenetic Reprogramming in Treatment-Resistant Malignancies: Emerging Therapeutic Targets and Clinical Implications
The persistent challenge of therapeutic resistance in oncology necessitates a paradigmatic shift towards understanding the dynamic epigenetic landscape governing malignant phenotype and drug responsiveness. This comprehensive review examines histone deacetylase (HDAC) inhibitors, bromodomain and extra-terminal (BET) inhibitors, and DNA methyltransferase (DNMT) modulators as rational therapeutic strategies to overcome acquired resistance mechanisms while preserving genomic stability.…
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Why Cancer Medicines Stop Working
Why Cancer Medicines Stop Working Cancer is a very serious disease. Doctors give patients medicine to fight cancer. But sometimes the medicine stops working. The cancer cells learn to hide from the medicine. This article explains why this happens. How Do Cells Work? Every cell in your body has instructions. These instructions are called DNA.…
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Physician Epigenetic Reprogramming in Treatment-Resistant Malignancies: Emerging Therapeutic Targets and Clinical Implications
The persistent challenge of therapeutic resistance in oncology necessitates a paradigmatic shift towards understanding the dynamic epigenetic landscape governing malignant phenotype and drug responsiveness. This comprehensive review examines histone deacetylase (HDAC) inhibitors, bromodomain and extra-terminal (BET) inhibitors, and DNA methyltransferase (DNMT) modulators as rational therapeutic strategies to overcome acquired resistance mechanisms while preserving genomic stability.…
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AI Isn’t Magic—It’s a Tool
Artificial Intelligence has become one of the most hyped technologies of our time. Every company seems to be rushing to implement AI in some form, often with unclear goals and unrealistic expectations. At Proud Nerds, we’ve learned that the most valuable AI implementations are those that solve real, specific business problems. AI Isn’t Magic—It’s a…
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Understanding Your Users
In today’s digital landscape, having a website isn’t enough. Your digital presence needs to be strategic, user-centered, and purposeful. At Proud Nerds, we’ve learned that successful digital transformation starts long before the first line of code is written. The Foundation: Understanding Your Users Many companies rush into development thinking that building more features will automatically…